Researchers develop highly specific apoptosis assay for pharmacodynamic analyses of tumor specimens

Existing microscopy-based methods of detecting apoptosis, such as TUNEL (terminal deoxynucleotidyl transferase dUTP nick-end labeling), have limited quantitative capabilities due to insufficient signal-to-noise ratios. Researchers at the National Cancer Institute and National Cancer Institute-Frederick have addressed this issue via development of a highly specific apoptosis assay designed for immunofluorescence microscopy analysis of fixed core needle […]

Low-cost deworming drug improves female farmers’ physical fitness

Impoverished female farm workers infected with intestinal parasites known as hookworms saw significant improvements in physical fitness when they were treated with a low-cost deworming drug. The benefits were seen even in those with low level infections, according to a study co-authored by researchers at Yale and the nonprofit company InnovationsCZ. The authors say that […]

People diagnosed with traumatic brain injury may have increased risk of Parkinson’s disease, shows study

People who have been diagnosed with a mild concussion, or mild traumatic brain injury, may have a 56 percent increased risk of developing Parkinson’s disease, according to a study published in the April 18, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology. “Previous research has shown a strong link […]

Researcher presents case study of asymptomatic patient with severe mitral regurgitation

In the current issue of Cardiovascular Innovations and Applications (Volume 2, Number 4, 2018, pp 431-434(4); DOI: https://doi.org/10.15212/CVIA.2017.0034, researcher Blase A. Carabello, from East Carolina University, Greenville, NC, USA presents a case study of an asymptomatic patient with severe mitral regurgitation. In primary mitral regurgitation there are anatomic abnormalities of the mitral valve causing backward […]

New IntelliCyt Cy-Clone PLUS streamlines clone ranking and selection for cell line development

The IntelliCyt Cy-Clone™ PLUS Assay System will accelerate and improve the quality of clone ranking and selection for developing cell lines which can reduce production costs of biopharmaceuticals. IntelliCyt, a Sartorius Company, and a leading provider of integrated platforms that accelerate drug discovery, antibody screening and immuno-oncology research today announced the launch of the Cy-Clone […]

IntelliCyt announces acquisition by Sartorius

Acquisition Substantially Strengthens Premier Portfolio of Life Sciences Research Tools for Cell Analysis and Bioprocessing IntelliCyt, a leading provider of integrated platforms that accelerate drug discovery, antibody screening and immuno-oncology research, announced today it has been acquired by Sartorius, a leading international pharmaceutical and laboratory equipment provider. The transaction is for $90 million in cash; […]

Direct electrical current can be delivered to nerves for blocking pain signals

Using computer models and laboratory rats, Johns Hopkins researchers have demonstrated that “direct electrical current” can be delivered to nerves preferentially, blocking pain signals while leaving other sensations undisturbed. The researchers say the experiments advance the search for improved implantable devices able to treat chronic pain that is due to peripheral nerve injury or disease. […]