One step closer to finding a cure for brain diseases

Molecular model of PTP? signaling pathways in heterologous synapse formation. A) PTP? triggers excitatory heterologous synapse formation through a combination of extracellular and intracellular signaling components. The PTP? D2 domain binds intracellular adaptor proteins (e.g., liprin-?) and substrates (e.g., p250RhoGAP and N-cadherin) to recruit the vesicular machinery for excitatory synapse development. This signal transduction model […]