How does estrogen protect bones? Unraveling a pathway to menopausal bone loss

Related video Estrogen induces osteocyte expression of Sema3A, which acts on its receptor on osteocytes to promote survival, resulting in reduced osteoclastic bone resorption and enhanced osteoblastic bone formation. Sema3A-activated sGC-cGMP signaling through Nrp1 protected osteocytes from apoptosis. Credit: Department of Cell Signaling,TMDU Estrogen induces osteocyte expression of Sema3A, which acts on its receptor on […]

When neurons are out of shape, antidepressants may not work

Related video These are human serotonergic neuron projections (red) and cell bodies (green). Credit: Salk Institute These are human serotonergic neuron projections (red) and cell bodies (green). Credit: Salk Institute Close Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed medication for major depressive disorder (MDD), yet scientists still do not understand why the […]