Rare genetic disorders more complex than thought

Related video Researchers have found that the genetic causes of rare neurodevelopmental disorders vary more than previously thought. The study from Wellcome Sanger Institute scientists and their collaborators discovered that serious rare disorders can be affected by combinations of common genetic variants, rather than solely individual rare variants that damage single genes. The study published […]

Schizophrenia: ‘Resyncing’ brain circuits could halt symptoms

Related video Dysfunctional inhibitory neurons Genetic and environmental origins A mouse model of schizophrenia We could restore ‘functional brain dynamics’ Schizophrenia is a complex mental condition that is still not fully understood in terms of how brain circuitry links up to behavioral symptoms. Now, however, scientists seem to have found a way to make some […]

Resynchronizing neurons to erase schizophrenia

Related video Schizophrenia, an often severe and disabling psychiatric disorder, affects approximately 1% of the world’s population. While research over the past few years has suggested that desynchronization of neurons may be the cause of its neuropsychiatric symptoms, such as memory disorders, hyperactivity or hallucinatory phenomena, the cellular origin of such desynchronization remains poorly understood. […]

Overlapping copy number variations underlie autism and schizophrenia in Japanese patients

Related video This visual abstract depicts the comparative analyses of CNV in autism and schizophrenia. Credit: Itaru Kushima, Nagoya University Graduate School of Medicine This visual abstract depicts the comparative analyses of CNV in autism and schizophrenia. Credit: Itaru Kushima, Nagoya University Graduate School of Medicine Close Common genetic variants may underlie autism spectrum disorder […]

Targeting a brain mechanism could treat aggression

A number of psychiatric disorders present with aggression and violence, which, needless to say, are destructive to both individuals and societies worldwide: death, disease, disability, and numerous socioeconomic problems can often be traced back to aggressive behavior. But despite being common, aggression has proven very difficult to treat. Some pharmacological regimens can be of some […]