Breakthrough research reveals how deadly pneumococcus avoids immune defenses

Related video Scientists at the University of Liverpool have discovered a new and important function of a toxin produced by disease-causing bacteria that could have significant implications for future vaccine design. Streptococcus pneumoniae (the pneumococcus) is a major cause of life-threatening invasive diseases such as pneumonia, septicaemia and meningitis, and is responsible for more than […]

Bacterial pneumonia far more dangerous to the heart than viral pneumonia

Related video Heart complications in patients diagnosed with bacterial pneumonia are more serious than in patients diagnosed with viral pneumonia, according to new research from the Intermountain Heart Institute at Intermountain Medical Center in Salt Lake City. In the study of nearly 5,000 patients, researchers found that patients diagnosed with bacterial pneumonia had a 60 […]

Artificial intelligence may fall short when analyzing data across multiple health systems

Related video Artificial intelligence (AI) tools trained to detect pneumonia on chest X-rays suffered significant decreases in performance when tested on data from outside health systems, according to a study conducted at the Icahn School of Medicine at Mount and published in a special issue of PLOS Medicine on machine learning and health care. These […]

Report: Persistent inequities may hamper progress to stop child pneumonia and diarrhea deaths

Related video Globally, pneumonia and diarrhea together led to nearly one of every four deaths that occurred in children under five years of age in 2016. The 2018 Pneumonia and Diarrhea Progress Report–released ahead of the 10th annual World Pneumonia Day, on November 12, by the International Vaccine Access Center (IVAC) at the Johns Hopkins […]

AI in medical space must be carefully tested for performance across wide range of populations

Related video Artificial intelligence (AI) tools trained to detect pneumonia on chest X-rays suffered significant decreases in performance when tested on data from outside health systems, according to a study conducted at the Icahn School of Medicine at Mount and published in a special issue of PLOS Medicine on machine learning and health care. These […]

Pathogens may evade immune response with metal-free enzyme required for DNA replication

Related video A metal-free ribonucleotide reductase–an enzyme required for DNA replication–from bacterial pathogens uses a post-translationally modified amino acid (pictured) to initiate an essential DNA biosynthesis reaction. The modification (indicated by arrow) is essential for initiation of ribonucleotide reduction. This metal-free enzyme could allow microbes associated with strep throat and pneumonia infections to more effectively […]

Prevalence of virulent K. pneumoniae strains among neonates is higher than was previously thought

Related video The research was conducted by Kazan Federal University, Kazan State Medical University, City Clinical Children’s Hospital N 1, and Republican Clinical Infectious Diseases Hospital. K. pneumoniae is known to cause a number of infectious diseases of lungs, kidneys, intestines, liver, and blood. It has become widely known in recent years because of quickly […]

First experiments at new X-ray laser reveal unknown structure of antibiotics killer

Related video Artist’s impression of the experiment: When the ultra-bright X-ray flashes (violet) hit the enzyme crystals in the water jet (blue), the recorded diffraction data allow to reconstruct the spatial structure of the enzyme (right). Credit: DESY/Lucid Berlin Artist’s impression of the experiment: When the ultra-bright X-ray flashes (violet) hit the enzyme crystals in […]