Pathogens may evade immune response with metal-free enzyme required for DNA replication

Related video A metal-free ribonucleotide reductase–an enzyme required for DNA replication–from bacterial pathogens uses a post-translationally modified amino acid (pictured) to initiate an essential DNA biosynthesis reaction. The modification (indicated by arrow) is essential for initiation of ribonucleotide reduction. This metal-free enzyme could allow microbes associated with strep throat and pneumonia infections to more effectively […]

Prevalence of virulent K. pneumoniae strains among neonates is higher than was previously thought

Related video The research was conducted by Kazan Federal University, Kazan State Medical University, City Clinical Children’s Hospital N 1, and Republican Clinical Infectious Diseases Hospital. K. pneumoniae is known to cause a number of infectious diseases of lungs, kidneys, intestines, liver, and blood. It has become widely known in recent years because of quickly […]

First experiments at new X-ray laser reveal unknown structure of antibiotics killer

Related video Artist’s impression of the experiment: When the ultra-bright X-ray flashes (violet) hit the enzyme crystals in the water jet (blue), the recorded diffraction data allow to reconstruct the spatial structure of the enzyme (right). Credit: DESY/Lucid Berlin Artist’s impression of the experiment: When the ultra-bright X-ray flashes (violet) hit the enzyme crystals in […]

What is bronchopneumonia?

Related video What is bronchopneumonia? Symptoms Causes and risk factors Complications Diagnosis Treatment Prevention Takeaway Bronchopneumonia is a type of pneumonia, a condition that causes inflammation of the lungs. Symptoms can range from mild to severe and may include coughing, breathing difficulties, and fever. Causes include bacterial, viral, or fungal chest infections. According to the […]

Pfizer’s 20vPnC vaccine receives Breakthrough Therapy designation from FDA

Related video Pfizer Inc. announced today that its 20-Valent Pneumococcal Conjugate Vaccine (20vPnC) candidate, PF-06482077, received Breakthrough Therapy designation from the US Food and Drug Administration (FDA) for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae serotypes in the vaccine in adults aged 18 years and older. Pfizer expects to start Phase […]

Tongue microbiome research underscores importance of dental health

Elderly individuals with fewer teeth, poor dental hygiene, and more cavities constantly ingest more dysbiotic microbiota, which could be harmful to their respiratory health, according to new research published in the journal mSphere. The findings come from a large, population-based study that identified variations in the tongue microbiota among community-dwelling elderly adults in Japan. “Fewer […]

Biomarker discovered for pathogen that can blind or kill healthy young people

This is a human neutrophil (grey) is interacting with Klebsiella pneumoniae (pink). A hypervirulent version of this pathogen is sparking increasing concern. Credit: National Institute of Allergy and Infectious Disease This is a human neutrophil (grey) is interacting with Klebsiella pneumoniae (pink). A hypervirulent version of this pathogen is sparking increasing concern. Credit: National Institute […]