Genome editing identifies neural circuit behind leptin’s anti-obesity and anti-diabetes effects

Revealing surprising answers to a long-standing enigma about the brain target of the anti-obesity hormone leptin, neuroscientists at Tufts University School of Medicine have used CRISPR genome editing to identify a neural circuit in the hypothalamus as the primary mechanism in mediating leptin’s anti-obesity and anti-diabetes effects and have identified two distinct mechanisms underlying leptin’s […]

Leptin’s neural circuit identified

Infrared thermal image of mouse littermates after CRISPR genome editing of leptin signaling. Genetic disruption of leptin receptors in hypothalamus caused obesity and diabetes (top) compared with control (bottom). Credit: Peiyuan Zhang for Tufts University Infrared thermal image of mouse littermates after CRISPR genome editing of leptin signaling. Genetic disruption of leptin receptors in hypothalamus […]