Cancer cells thrive in stiff tissue

Stiffer breast tissue creates an environment more prone to cancer by enabling the disease to interfere with the surrounding healthy cells, according to a recent study published in Biomaterials. Scientists studying tumor growth and metastasis at the University of Notre Dame fabricated a human tissue model to examine how cancer cells interact with connective tissue […]

New approach to starve p53 deficient tumors

One major hallmark of cancer cells is their ability to adapt to stressful conditions such as nutrient deprivation. Rapidly growing tumor cells must compete for the ever-diminishing supply of nutrients in the surrounding environment to survive and proliferate. Targeting these adaptive mechanisms represents a promising approach for cancer therapeutics. Sanford Prebys Medical Discovery Institute (SBP) […]

Madagascar periwinkle research uncovers pathway to cancer-fighting drugs

Breakthrough research has unraveled the complex chemistry of Madagascar periwinkle. the plant produces the cancer-fighting compound vinblastine. Credit: Andrew Davis – John Innes Centre Breakthrough research has unraveled the complex chemistry of Madagascar periwinkle. the plant produces the cancer-fighting compound vinblastine. Credit: Andrew Davis – John Innes Centre Close Plant scientists have taken the crucial […]

University of Miami’s Otolaryngology department receives NIH grant for research training

The University of Miami Miller School of Medicine’s Department of Otolaryngology-Head and Neck Surgery is one of eight otolaryngology training programs in the U.S. to receive the Ruth L. Kirschstein National Research Service Award Institutional Research Training Grant (T32) for interdisciplinary research training in otolaryngology. Research conducted under this grant is supported by the National […]

Penn State professor receives NSF CAREER award to study mechanobiology of cell differentiation

Esther Gomez, assistant professor of chemical engineering and biomedical engineering, Penn State, has received the National Science Foundation’s (NSF) prestigious Early Career (CAREER) award to better understand the mechanobiology of mesenchymal-epithelial transition (MET). MET is a cell differentiation process in which a cell transitions from a moving cell to a stationary cell. This transition is […]