Unlocking the secrets of a cancer-fighting flower

The trouble with vinblastine The 31 steps to vinblastine A chemical extracted from a small flowering plant has helped in the fight against cancer for decades. Now, after a 60-year hunt, scientists have finally uncovered how it creates this medically important molecule. This small flowering plant houses an inscrutable chemical processing plant. The Madagascar periwinkle, […]

FDA grants approval for two drugs administered together to treat aggressive form of thyroid cancer

The U.S. Food and Drug Administration approved Tafinlar (dabrafenib) and Mekinist (trametinib), administered together, for the treatment of anaplastic thyroid cancer (ATC) that cannot be removed by surgery or has spread to other parts of the body (metastatic), and has a type of abnormal gene, BRAF V600E (BRAF V600E mutation-positive). “This is the first FDA-approved […]

Preclinical study suggests ARID1a mutations may help predict immunotherapy success

Functional loss of ARID1a, a frequently mutated tumor suppressor gene, causes deficiencies in normal DNA repair and may sensitize tumors to immune checkpoint blockade therapies, according to researchers from The University of Texas MD Anderson Cancer Center. The preclinical study suggests that mutations in ARID1a could be beneficial in predicting immunotherapy success. The findings, published […]