Making digital tissue imaging better

Related video There’s a low-tech problem troubling the high-tech world of digital pathology imaging. The issue: Even as digital pathology makes rapid advances worldwide — with more physicians analyzing tissue images on “smart” computers to diagnose patients — there are no reliable standards for the preparation and digitization of the tissue slides themselves. That means […]

Scientists advance creation of ‘artificial lymph node’ to fight cancer, other diseases

Related video Close In a proof-of-principle study in mice, scientists at Johns Hopkins Medicine report the creation of a specialized gel that acts like a lymph node to successfully activate and multiply cancer-fighting immune system T-cells. The work puts scientists a step closer, they say, to injecting such artificial lymph nodes into people and sparking […]

New software aims to reduce variability in ELISA biomarker tests

Related video A new computational approach has been developed to reduce variability in common research biomarker tests, a promising step in improving the ability of biomedical researchers and basic scientists to reproduce data and facilitate more consistent results across laboratories and long-term projects. Researchers from Boston Medical Center (BMC) and Boston University School of Medicine […]

Bacterial therapy in a dish

Related video The image shows engineered bacteria (green) in tumor spheroids cultured in a multi-well plate. Credit: Tetsuhiro Harimoto/Columbia Engineering The image shows engineered bacteria (green) in tumor spheroids cultured in a multi-well plate. Credit: Tetsuhiro Harimoto/Columbia Engineering Close Engineering bacteria to intelligently sense and respond to disease states, from infections to cancer, has become […]

Factors behind embryonic stem cell state

Related video Embryonic stem cells (ESC) have the ability to self-renew, and, being pluripotent have the potential to create almost any cell type in the body. The embryonic stem cell state is established and maintained by multiple regulatory networks that include epigenetic regulators; the function of these epigenetic regulators though has not been well-defined. An […]

Fragments of cellular machinery reveal unexpected variability among cancers

Related video Cancer is a disease of dysregulated gene expression. Now, researchers from Jefferson (Philadelphia University + Thomas Jefferson University) find that a new, large category of molecules called transfer RNA (tRNA)-derived fragments have extensive interconnections to gene templates and gene products that differ by cancer type. Moreover, these interconnections can be impacted by the […]