How small molecule halts spread of toxic protein associated with Alzheimer’s progression

Model of cambinol (yellow) binding to nSMase2 shown with electrostatic potential. Blue for positive charge, red for negative charge, and white is for neutral charge. Credit: UCLA Drug Discovery and Translational Lab Model of cambinol (yellow) binding to nSMase2 shown with electrostatic potential. Blue for positive charge, red for negative charge, and white is for […]

Two is better than one to improve brain function in Alzheimer’s disease mouse model

Using two complementary approaches to reduce the deposits of amyloid-beta in the brain rather than either approach alone improved spatial navigation and memory in a mouse model of Alzheimer’s disease. These findings suggest that similar combination treatments also might help patients with Alzheimer’s disease in the future. The study appears in the Journal of Experimental […]

Study reveals increased risks for Alzheimer’s, suicide among youth in polluted cities

A University of Montana researcher and her collaborators have published a new study that reveals increased risks for Alzheimer’s and suicide among children and young adults living in polluted megacities. Dr. Lilian Calderón-Garcidueñas said her group studied 203 autopsies of Mexico City residents ranging in age from 11 months to 40 years. Metropolitan Mexico City […]

Evidence mounts for Alzheimer’s, suicide risks among youth in polluted cities

This is pollution haze over Mexico City. Credit: Lilian Calderón-Garcidueñas This is pollution haze over Mexico City. Credit: Lilian Calderón-Garcidueñas Close A University of Montana researcher and her collaborators have published a new study that reveals increased risks for Alzheimer’s and suicide among children and young adults living in polluted megacities. Dr. Lilian Calderón-Garcidueñas said […]

Alzheimer’s disease redefined: New research framework defines Alzheimer’s by brain changes, not symptoms

“NIA-AA Research Framework: Towards a Biological Definition of Alzheimer’s Disease” was published today in the April 2018 issue of Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. First author Clifford R. Jack, Jr., M.D., of Mayo Clinic Rochester, MN and colleagues propose shifting the definition of Alzheimer’s disease in living people — for use […]