How does estrogen protect bones? Unraveling a pathway to menopausal bone loss

Related video Estrogen induces osteocyte expression of Sema3A, which acts on its receptor on osteocytes to promote survival, resulting in reduced osteoclastic bone resorption and enhanced osteoblastic bone formation. Sema3A-activated sGC-cGMP signaling through Nrp1 protected osteocytes from apoptosis. Credit: Department of Cell Signaling,TMDU Estrogen induces osteocyte expression of Sema3A, which acts on its receptor on […]

When neurons are out of shape, antidepressants may not work

Related video These are human serotonergic neuron projections (red) and cell bodies (green). Credit: Salk Institute These are human serotonergic neuron projections (red) and cell bodies (green). Credit: Salk Institute Close Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed medication for major depressive disorder (MDD), yet scientists still do not understand why the […]

Sleep problems, Alzheimer’s disease are linked, but which comes first?

Related video A new article explores the pathophysiological factors that link sleep disturbances and Alzheimer’s disease. Better understanding of this connection may lead to potential diagnostics and therapeutics for Alzheimer’s disease and other neurodegenerative diseases and dementia. The article is published ahead of print in the Journal of Neurophysiology (JNP). Alzheimer’s research has largely focused […]

Aspiring doctors seek advanced training in addiction medicine

Related video The U.S. Surgeon General’s office estimates that more than 20 million people have a substance use disorder. Meanwhile, the nation’s drug overdose crisis shows no sign of slowing. Yet, by all accounts, there aren’t nearly enough physicians who specialize in treating addiction — doctors with extensive clinical training who are board-certified in addiction […]