A diet based on low calories, and led to intermittent periods, would help reduce the chronic pain caused by neuralgia
To reveal the analgesic power of fasting is an Italian study conducted on an animal model and published in the journal Faseb has identified the possible involvement of a new receptor in pain perception due to peripheral neuropathy. Neuropathic pain, such as that caused by sciatica, back pain, cervical caused by hernias, or amputated limbs, not responding to most of the classic analgesics. Today, “the treatments involve drugs, antidepressants, anticonvulsants, and supportive treatments, psycho-cognitive,” explains the coordinator of the research team, Sabatino Maione, professor of Pharmacology at the University of the Campania region, Luigi Vanvitelli. Consequently, he adds, “there is a considerable research interest in identifying new molecular mechanisms to better understand the nature”. Studying transgenic mice, researchers have identified, for the first time, the potential analgesic receptor HCAR2, demonstrating that significantly reduces the alteration of the threshold associated with neuropathic pain. By studying mice subjected to two days of fasting, explains one of the researchers, Livio Luongo, “we have had confirmation that this receptor HCAR2, is stimulated by beta-hydroxy-butyrate (BHB) is a ketone that is produced in larger quantities by prolonged fasting or a diet very low sugar content. In this case, the pain becomes less, but also very treatable with drugs. ” The results offer hope of potential therapies that would make life better in this type of patients. The involvement of the receptor HCAR2, conclude the researchers, may open new treatment possibilities, “based on the association between the pharmacology and diets such as fasting or the ketogenic diet”. .