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It was previously believed that fructose, which is the sugar found in fruit and fruit juice, is processed by the liver. However, a new study suggests that fructose is mainly processed in the small intestine.
Researchers reveal that fructose is primarily processed in the small intestine, not the liver.
The study, which is published in the journal Cell Metabolism, reveals that processed high-sugar food and drink only spills over into the liver for processing when the small intestine becomes overwhelmed.
The recent findings add to the body of scientific knowledge on the effects of too much fructose on the body.
We know from previous research that excessive consumption of sugar is harmful to the liver, and that chronic overconsumption causes obesity, increases resistance to insulin, and creates conditions for the onset of diabetes.
Last year, Medical News Today reported on a study that found that fructose-containing products such as sweetened drinks can increase the risk of non-alcoholic steatohepatitis, a form of non-alcoholic fatty liver disease, “which can lead to cirrhosis or liver cancer.”
Study observed fructose digestion in mice
The researchers, from Princeton University in New Jersey, used mice to study how fructose travels through the digestive system. Their findings suggest that there is a physiological difference in how the body processes different amounts of sugar.
Rather than the liver processing all the sugar in the body, the team observed that more than 90 percent of fructose was processed in the small intestines of the mice in the study.
The team found that fructose not absorbed into the small intestine is passed through to the colon, where it comes into contact with the microbiome, which is the microbiotic flora that inhabits the large intestine and colon.
Fruit juices and smoothies have ‘unacceptably high’ sugar content
Researchers reveal that a child’s entire daily sugar allowance could be in one serving of fruit juice.
The researchers explain that the microbiome is not designed to process sugar. So, while a person could eat a large amount of carbohydrates without exposing their microbiome to any sugar, this changes significantly when high-sugar products — such as soda and juice — are consumed.
While the findings do not prove that fructose influences the microbiome, the team believes that “an effect is likely.” They suggest that this link should be further investigated in future studies, as it may provide new insights into the adverse effects of high sugar intake.