Smoke, a test

Smoke, a test to choose therapies tailored to stop

A genetic test will allow to define therapeutic pathways customized to be able to quit smoking more easily

And this is the most evident consequence of a study by researchers of the Istituto Nazionale dei Tumori (INT) Milano, published in Scientific Reports, a journal of the Nature group. In particular, working on a simple blood sample, researchers have identified the genetic characteristics of the individual that influence the risk of becoming dependent on cigarette smoking or even the difficulty to stop smoking even with the help of a drug therapy. Some variations in DNA, specific for each individual, localized in the genes that determine the receptors of the nicotine – explain the researchers – were associated with the risk of becoming dependent just from the nicotine. In particular, some of these changes also increased the difficulty of quitting smoking in patients who have taken the specific drug treatments, smoke, and have received a special psychological support. The results of the study also confirmed that smoking cessation and, especially, ‘not resume’ is not easy. In fact, although shortly after the beginning of therapy, smoke-free, more than 70% of the subjects managed to quit smoking, a year, from the beginning of the treatment, many have fallen into smoking addiction, and only 47% of subjects had finally stopped.

“These results – said Francesca Colombo, a researcher at the Unit of Genetic Epidemiology and Pharmacogenomics of the INT, over which the coordinator of the study – they represent the first step towards the identification of a genetic profile of the individual, on the basis of which you will be able to define a course of treatment of smoking cessation, the more personalized as possible.

” “In this way you will be able to increase the number of patients that will benefit from the various therapies smoke available, – observes Roberto Boffi, Head of Pneumology and of the anti-smoking Centre of the INT – diagnosing the type of smoker that you reach out to us, as well as to help him concretely in his cessation attempt and to reduce at the same time the incidence of diseases smoking-related”. .

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