Watch out for

Watch out for the symptoms of the common cold in infants

It’s a cold which is an even if it looks like him, but he is not due to a rhinovirus

He can think of flu, because it causes near symptoms, but is not the same virus. No, it is a pneumovirus, the virus respiratory syncytial (RSV for Respiratory Syncytial Virus). Highly contagious, it causes usually as a cold-like symptoms.

But infants less than 2 years, it can be very dangerous, triggering serious pneumonia. Researchers from the medical school of Washington University in St. Louis, led by Daisy Leung, strove to find the reason why this virus can evade radars of the immune system. And have the beginnings of replies (papers published in Nature Microbiology).

It is estimated that each year 34 million of infections to the RSV in children less than 5 years ago.

It is estimated that 34 million of infections to the RSV in children less than 5 years, including 10% are severe forms with about 100 each year.  000 deaths (2005 figures). The elderly or those who are immunocompromised are also the targets of choice.

There is no licensed vaccine and treatment is limited. The antiviral Ribavirin, dear, of moderate effectiveness, is thus used as a last resort.

The virus takes advantage of any weakness of the immune system to multiply. Daisy Leung and his colleagues already knew that it is through a mysterious protein called NS1, the virus “confuses” the cells of the immune system. By x-ray crystallography, they were able to determine this protein 3D structure in order to ‘draw’ it in all its details. And they spotted part of NS1, alpha-3 propeller, which seemed them to be a centerpiece of the cloak of invisibility of the virus. This has been proven by creating viruses devoid of this propeller. Without it, the virus was more immune radars. “Now that we have the structure of NS1, we have identified the key part of the protein, we should be able to find out how she is, says Daisy Leung. This should help find treatments and an effective vaccine. ” “Big Bang health, House of chemistry in Paris, October 26, 2017, from 8 h 30 to 19 hours ‘ check out the 2nd edition 2017 .

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